Endocrine Abstracts

We present the case of a 58 years old woman with a long history of Graves’ disease and mild hypercalcaemia (total calcium registered a maximum of 11.1 mg/dl) that was first interpreted as a consequence of hyperthyroidia. After 10 year of being treated with anti-thyroid drugs the patient finally decides to undergo surgery. Immediately after surgery this particular patient does not develop hypoparathyroidism, her calcium level remaining a little high. Six weeks after surger...

We present the case of a 33-year-old male who addresses an endocrinology service for the first time in May 2014 for marked asthenia, drowsiness, muscular aches, and a delay in growing. The physiological exam showed difficulties in communicating and relation with the others based on his own negative image of himself, lack of self- trust, auto-isolation tendency, state of depression. We raised the suspicion of a panhypopitutarism confirmed by the lab exams that describe a somato...

Background: Osteoporosis has been an excruciating disease for many years now. Although various treatments are available, there is an unmet need for disease prognosis, early disease diagnosis and prediction of treatment efficacy. New biomarkers are crucial for the diagnosis or prognosis of a disease as well as for monitoring treatment efficacy and improve decision making. Cathepsin K is a cysteine protease that cleaves collagen type I, the major type of collagen found in bone, ...

We present the case of a patient diagnosed with panhypopituitarism at an adult age. The tenth child of a poor family, PA consulted the endocrinologist accompanied by his 65 year old mother. PA was 20 years old at the first consultation. He was, however, entrapped in the body of a 12 year old child, being only 139 cm tall and having no signs of puberty onset. He was slightly eunuchoid, with long limbs, due to delayed puberty, with micropenis and lack of androgen dependent hair,...

Body weight is positively correlated to bone mass. While gravity represents a stimulation stress for bone turnover, endocrine function of adipocytes may also influence bone.Objectives: We investigated the relative influence of weight, body composition and leptin upon lumbar bone mass in pre and postmenopausal women.Materials and methods: Cross-sectional study including six groups varying from 8 to 15 pre- / postmenopausal healthy v...

We present the case of a 75-year-old woman with a 10-year history of nephrolithiasis, for which she endured several sessions of extracorporeal shockwave lithotripsy (ESWL). She was directed to the Endocrinology unit for further investigations, due to persistent albeit minor increased values of blood calcium (10.48 mg/dl, normal 8.4–10.2 mg/dl). Here, the clinical supposition of primary hyperparathyroidism was confirmed. The tests revealed a mild hypercalcemia with hypopho...

Introduction: Body weight is positively correlated to bone mineral density. The exact mechanism is unclear but gravity may be one of the involved factors. Adipocytokines (leptin and adiponectin), secreted by the adipose tissue, are involved in bone turnover. We investigated the influence of body weight, body composition, and adipocytokines upon bone mass in pre and postmenopausal women.Design: Cross-sectional study including six groups of 8 to 16 healthy...

We describe two very rare genetic diseases characterized by particular physical features and deviation from normal growth. The first patient, CM, was admitted for delayed growth (113 cm at 8 years of age, -3 S.D.). The child had short lower arms with small hands and clinodactyly of the fifth finger. He had round widely spaced eyes with long eyelashes, a flat profile and prominent forehead, short upturned nose, misaligned teeth and gum hypertrophy. We diagnosed a...

Papillary carcinoma is the most common differentiated malignant thyroid neoplasm. Metastasis commonly occur in regional lymph nodes and distant metastasis ia a late and rare occurrence.Papillary thyroid carcinoma with metastasis to the parietal skull is very rare.We present the case of a parital skull metastasis arising from a papillary carcinoma prior to the diagnosis of thyroid tumor. The patient was a 58 caucasian woman with pre...